Association of C1QB gene polymorphism with schizophrenia in Armenian population.

ABSTRACT:

Background

Schizophrenia is a complex, multifactorial psychiatric disorder. Our previous findings indicated that altered functional activity of the complement system, a major mediator of the immune response, is implicated in the pathogenesis of schizophrenia. In order to explore whether these alterations are genetically determined or not, in the present study we evaluated the possible association of complement C1Q component gene variants with susceptibility to schizophrenia in Armenian population, focusing on four frequent single nucleotide polymorphisms (SNPs) of C1QA and C1QB genes.

Methods

In the present study four SNPs of the complement C1Q component genes (C1QA: rs292001, C1QB rs291982, rs631090, rs913243) were investigated in schizophrenia-affected and healthy subjects

SUBMITTER: Zakharyan R 

PROVIDER: S-EPMC3192735 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature