Enteric microbiome metabolites correlate with response to simvastatin treatment.

ABSTRACT: Although statins are widely prescribed medications, there remains considerable variability in therapeutic response. Genetics can explain only part of this variability. Metabolomics is a global biochemical approach that provides powerful tools for mapping pathways implicated in disease and in response to treatment. Metabolomics captures net interactions between genome, microbiome and the environment. In this study, we used a targeted GC-MS metabolomics platform to measure a panel of metabolites within cholesterol synthesis, dietary sterol absorption, and bile acid formation to determine metabolite signatures that may predict variation in statin LDL-C lowering efficacy. Measurements were performed in two subsets of the total study population in the Cholesterol and Pharmacogenetics (CAP) stud

SUBMITTER: Kaddurah-Daouk R 

PROVIDER: S-EPMC3192752 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature