Heat shock partially dissociates the overlapping modules of the yeast protein-protein interaction network: a systems level model of adaptation.

ABSTRACT: Network analysis became a powerful tool giving new insights to the understanding of cellular behavior. Heat shock, the archetype of stress responses, is a well-characterized and simple model of cellular dynamics. S. cerevisiae is an appropriate model organism, since both its protein-protein interaction network (interactome) and stress response at the gene expression level have been well characterized. However, the analysis of the reorganization of the yeast interactome during stress has not been investigated yet. We calculated the changes of the interaction-weights of the yeast interactome from the changes of mRNA expression levels upon heat shock. The major finding of our study is that heat shock induced a significant decrease in both the overlaps and connections of yeast interactome modu

SUBMITTER: Mihalik A 

PROVIDER: S-EPMC3192799 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature