Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome.

ABSTRACT: A major question in evolutionary biology is how natural selection has shaped patterns of genetic variation across the human genome. Previous work has documented a reduction in genetic diversity in regions of the genome with low recombination rates. However, it is unclear whether other summaries of genetic variation, like allele frequencies, are also correlated with recombination rate and whether these correlations can be explained solely by negative selection against deleterious mutations or whether positive selection acting on favorable alleles is also required. Here we attempt to address these questions by analyzing three different genome-wide resequencing datasets from European individuals. We document several significant correlations between different genomic features. In particular, w

SUBMITTER: Lohmueller KE 

PROVIDER: S-EPMC3192825 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature