Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping.

ABSTRACT: The extraordinary phenotypic diversity of dog breeds has been sculpted by a unique population history accompanied by selection for novel and desirable traits. Here we perform a comprehensive analysis using multiple test statistics to identify regions under selection in 509 dogs from 46 diverse breeds using a newly developed high-density genotyping array consisting of >170,000 evenly spaced SNPs. We first identify 44 genomic regions exhibiting extreme differentiation across multiple breeds. Genetic variation in these regions correlates with variation in several phenotypic traits that vary between breeds, and we identify novel associations with both morphological and behavioral traits. We next scan the genome for signatures of selective sweeps in single breeds, characterized by long regions

SUBMITTER: Vaysse A 

PROVIDER: S-EPMC3192833 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature