Toll-8/Tollo negatively regulates antimicrobial response in the Drosophila respiratory epithelium.

ABSTRACT: Barrier epithelia that are persistently exposed to microbes have evolved potent immune tools to eliminate such pathogens. If mechanisms that control Drosophila systemic responses are well-characterized, the epithelial immune responses remain poorly understood. Here, we performed a genetic dissection of the cascades activated during the immune response of the Drosophila airway epithelium i.e. trachea. We present evidence that bacteria induced-antimicrobial peptide (AMP) production in the trachea is controlled by two signalling cascades. AMP gene transcription is activated by the inducible IMD pathway that acts non-cell autonomously in trachea. This IMD-dependent AMP activation is antagonized by a constitutively active signalling module involving the receptor Toll-8/Tollo, the ligand Spätzle

SUBMITTER: Akhouayri I 

PROVIDER: S-EPMC3192845 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature