Nuclear transporters in a multinucleated organism: functional and localization analyses in Aspergillus nidulans.

ABSTRACT: Nuclear transporters mediate bidirectional macromolecule traffic through the nuclear pore complex (NPC), thus participating in vital processes of eukaryotic cells. A systematic functional analysis in Aspergillus nidulans permitted the identification of 4 essential nuclear transport pathways of a hypothetical number of 14. The absence of phenotypes for most deletants indicates redundant roles for these nuclear receptors. Subcellular distribution studies of these carriers show three main distributions: nuclear, nucleocytoplasmic, and in association with the nuclear envelope. These locations are not specific to predicted roles as exportins or importins but indicate that bidirectional transport may occur coordinately in all nuclei of a syncytium. Coinciding with mitotic NPC rearrangements, tra

SUBMITTER: Markina-Inarrairaegui A 

PROVIDER: S-EPMC3192866 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature