The effects of chronic treatment with mood stabilizers on the rat hippocampal post-synaptic density proteome.

ABSTRACT: Bipolar disorder is a devastating illness that is marked by recurrent episodes of mania and depression. There is growing evidence that the disease is correlated with disruptions in synaptic plasticity cascades involved in cognition and mood regulation. Alleviating the symptoms of bipolar disorder involves chronic treatment with mood stabilizers like lithium or valproate. These two structurally dissimilar drugs are known to alter prominent signaling cascades in the hippocampus, but their effects on the post-synaptic density complex remain undefined. In this work, we utilized mass spectrometry for quantitative profiling of the rat hippocampal post-synaptic proteome to investigate the effects of chronic mood stabilizer treatment. Our data show that in response to chronic treatment of mood sta

SUBMITTER: Nanavati D 

PROVIDER: S-EPMC3192943 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature