Thrombomodulin gene variants are associated with increased mortality after coronary artery bypass surgery in replicated analyses.

ABSTRACT:

Background

We tested the hypothesis that genetic variation in thrombotic and inflammatory pathways is independently associated with long-term mortality after coronary artery bypass graft (CABG) surgery.

Methods and results

Two separate cohorts of patients undergoing CABG surgery at a single institution were examined, and all-cause mortality between 30 days and 5 years after the index CABG was ascertained from the National Death Index. In a discovery cohort of 1018 patients, a panel of 90 single-nucleotide polymorphisms (SNPs) in 49 candidate genes was tested with Cox proportional hazard models to identify clinical and genomic multivariate predictors of incident death. After adjustment for multiple comparisons and clinical predictors of mortality, the homozygote minor allele

SUBMITTER: Lobato RL 

PROVIDER: S-EPMC3192987 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature