Development of appropriate equations for physiologically based pharmacokinetic modeling of permeability-limited and flow-limited transport.

ABSTRACT: Although the implementation of a flow-limited, well-stirred tank (WST) single-compartment tissue model in pharmacokinetics and toxicokinetics is widespread, its use is not always justified biophysically or physiologically. The WST model introduces a loss of biophysical detail, specifically the vascular space, which is present in the standard permeability-limited two-subcompartment (PLT) tissue model. To address this loss of detail when evaluating the in vivo kinetics of drugs, toxins, nutrients, and endogenous metabolites, a novel set of physiologically based pharmacokinetic tissue compartment equations is developed through application of an asymptotic approximation to a two-region vascular-extravascular system to arrive at a permeability-limited two-region asymptotically reduced (P-TAR) m

SUBMITTER: Thompson MD 

PROVIDER: S-EPMC3193163 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature