MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure.

ABSTRACT: To understand the process of cardiac aging, it is of crucial importance to gain insight into the age-related changes in gene expression in the senescent failing heart. Age-related cardiac remodeling is known to be accompanied by changes in extracellular matrix (ECM) gene and protein levels. Small noncoding microRNAs regulate gene expression in cardiac development and disease and have been implicated in the aging process and in the regulation of ECM proteins. However, their role in age-related cardiac remodeling and heart failure is unknown. In this study, we investigated the aging-associated microRNA cluster 17-92, which targets the ECM proteins connective tissue growth factor (CTGF) and thrombospondin-1 (TSP-1). We employed aged mice with a failure-resistant (C57Bl6) and failure-prone (C5

SUBMITTER: van Almen GC 

PROVIDER: S-EPMC3193380 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature