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Expanding role of ubiquitination in NF-?B signaling.

ABSTRACT: Best known for its role in targeting protein degradation by the proteasome, ubiquitin modification has also emerged as an important mechanism that regulates cell signaling through proteasome-independent mechanisms. The role of ubiquitin as a versatile signaling tag is characteristically illustrated in the NF-?B pathways, which regulate a variety of physiological and pathological processes in response to diverse stimuli. Here, we review the role of ubiquitination in different steps of the NF-?B signaling cascades, focusing on recent advances in understanding the mechanisms of protein kinase activation by polyubiquitin chains in different pathways that converge on NF-?B.

SUBMITTER: Liu S

PROVIDER: S-EPMC3193409 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature

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Expanding role of ubiquitination in NF-κB signaling.

Liu Siqi S Chen Zhijian J ZJ

Cell research 20101207 1

Best known for its role in targeting protein degradation by the proteasome, ubiquitin modification has also emerged as an important mechanism that regulates cell signaling through proteasome-independent mechanisms. The role of ubiquitin as a versatile signaling tag is characteristically illustrated in the NF-κB pathways, which regulate a variety of physiological and pathological processes in response to diverse stimuli. Here, we review the role of ubiquitination in different steps of the NF-κB s ...[more]

PMID: 21135871

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