Parental longevity and diabetes risk in the Diabetes Prevention Program.

ABSTRACT:

Background

Longevity clusters in families, and parental longevity may be associated with lower risk of chronic diseases in their children. It is unknown if diabetes risk is associated with parental longevity.

Methods

We evaluated participants in the Diabetes Prevention Program with a parental history questionnaire at study entry. We classified them into five groups: premature death (parental death at age < 50 years), parental longevity (living to at least 80 years), and three intermediate groups (alive by age 49 but dying at age 50-59, 60-69, or 70-79). Those with alive parents and younger than 80 years were excluded. We analyzed separately effects of paternal (n = 2,165) and maternal (n = 1,739) longevity on diabetes incidence and risk after an average follow-up of 3.2 year

SUBMITTER: Florez H 

PROVIDER: S-EPMC3193521 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature