Establishment of murine basal cell carcinoma allografts: a potential model for preclinical drug testing and for molecular analysis.

ABSTRACT: Dysregulated hedgehog (HH) signaling has been found in numerous cancers, suggesting that therapeutic targeting of this pathway may be useful versus a wide range of cancers. Basal cell carcinoma (BCC) is an excellent model system for studying the influence of the HH pathway on carcinogenesis because aberrant activation of HH signaling is crucial not only for the development of but also the maintenance of BCC. Genetically engineered BCC mouse models provide one important tool for the study of the biology of human BCCs and for evaluating therapeutic interventions, as these mice produce multiple genetically defined tumors within a relatively short period of time. However, these models remain expensive and cumbersome to use for large-scale preclinical drug testing. Here we report a method for g

SUBMITTER: Wang GY 

PROVIDER: S-EPMC3193585 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature