Antiretroviral therapy responses among children attending a large public clinic in Soweto, South Africa.

ABSTRACT:

Background

Antiretroviral therapy (ART) access with successful outcomes for children is expanding in resource-limited countries. The aim of this study was to determine treatment responses of children in a routine setting where first-line therapy with lopinavir/ritonavir is routinely included for young children.

Methods

Outpatient records of children who initiated ART between April 2004 and March 2008 at a government clinic in Soweto were reviewed. Children <3 years initiated ART with lopinavir/ritonavir and those ≥ 3 years initiated with efavirenz-containing regimens.

Results

ART was initiated at a median age of 4.3 years, 28.6% also received tuberculosis treatment. During 3155 child-years of follow-up (median follow-up 17 months), 132 children (6%) died giving a mort

SUBMITTER: Meyers TM 

PROVIDER: S-EPMC3193588 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature