Effects of dexmedetomidine on oxygenation during one-lung ventilation for thoracic surgery in adults.

ABSTRACT:

Study objective

To evaluate the effects of dexmedetomidine on hypoxic pulmonary vasoconstriction (HPV) and oxygenation during one-lung ventilation (OLV) in adults undergoing thoracic surgery.

Design

Prospective, randomized, double-blinded trial.

Setting

Tertiary care, University-based hospital.

Patients

Nineteen adult patients undergoing thoracic surgery requiring OLV.

Interventions

During inhalational anesthesia with desflurane, patients were randomized to receive either dexmedetomidine (bolus dose of 0.3 μg/kg followed by an infusion of 0.3 μg/kg/hr) or saline placebo.

Measurements

Three arterial blood gas samples (ABG) were obtained to evaluate the effects of dexmedetomidine on oxygenation. Secondary outcomes included differences in hemodynamic

SUBMITTER: Kernan S 

PROVIDER: S-EPMC3193692 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature