MRNA expression profiles of primary high-grade central osteosarcoma are preserved in cell lines and xenografts.

ABSTRACT:

Background

Conventional high-grade osteosarcoma is a primary malignant bone tumor, which is most prevalent in adolescence. Survival rates of osteosarcoma patients have not improved significantly in the last 25 years. Aiming to increase this survival rate, a variety of model systems are used to study osteosarcomagenesis and to test new therapeutic agents. Such model systems are typically generated from an osteosarcoma primary tumor, but undergo many changes due to culturing or interactions with a different host species, which may result in differences in gene expression between primary tumor cells, and tumor cells from the model system. We aimed to investigate whether gene expression profiles of osteosarcoma cell lines and xenografts are still comparable to those of the primary tumo

SUBMITTER: Kuijjer ML 

PROVIDER: S-EPMC3193807 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature