FluReF, an automated flu virus reassortment finder based on phylogenetic trees.

ABSTRACT:

Background

Reassortments are events in the evolution of the genome of influenza (flu), whereby segments of the genome are exchanged between different strains. As reassortments have been implicated in major human pandemics of the last century, their identification has become a health priority. While such identification can be done "by hand" on a small dataset, researchers and health authorities are building up enormous databases of genomic sequences for every flu strain, so that it is imperative to develop automated identification methods. However, current methods are limited to pairwise segment comparisons.

Results

We present FluReF, a fully automated flu virus reassortment finder. FluReF is inspired by the visual approach to reassortment identification and uses the reconstr

SUBMITTER: Yurovsky A 

PROVIDER: S-EPMC3194234 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature