Ontology highlight
ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC3195361 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry 20110804 18
The integrin α(v)β(6) is an emergent biomarker for non-small cell lung cancer (NSCLC) as well as other carcinomas. We previously developed a tetrameric peptide, referred to as H2009.1, which binds α(v)β(6) and displays minimal affinity for other RGD-binding integrins. Here we report the use of this peptide to actively deliver paclitaxel to α(v)β(6)-positive cells. We synthesized a water soluble paclitaxel-H2009.1 peptide conjugate in which the 2'-position of paclitaxel is attached to the tetrame ...[more]