Pharmacological modulation of stress-induced behavioral changes in the light/dark exploration test in male C57BL/6J mice.

ABSTRACT: Psychological stress is a major risk factor for mood and anxiety disorders. However, the phenotypic manifestation of stress effects varies across individuals, likely due, in part, to genetic variation. Modeling the behavioral and neural consequences of stress across genetically diverse inbred mouse strains is a valuable approach to studying gene × stress interactions. Recent work has shown that C57BL/6J mice exposed to ten daily sessions of restraint stress exhibited increased exploration of the aversive light compartment in the light/dark exploration (LDE) test. Here we sought to clarify the nature of this stress-induced phenotype by testing the ability of treatment with various clinically efficacious drugs of different therapeutic classes to rescue it. Ten days of restraint increased lig

SUBMITTER: Ihne JL 

PROVIDER: S-EPMC3195838 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature