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Triclabendazole protects yeast and mammalian cells from oxidative stress: identification of a potential neuroprotective compound.

ABSTRACT: The Prestwick and NIH chemical libraries were screened for drugs that protect baker's yeast from sugar-induced cell death (SICD). SICD is triggered when stationary-phase yeast cells are transferred from spent rich medium into water with 2% glucose and no other nutrients. The rapid, apoptotic cell death occurs because reactive oxygen species (ROS) accumulate. We found that triclabendazole, which is used to treat liver flukes in cattle and man, partially protects against SICD. Characterization of triclabendazole revealed that it also protects yeast cells from death induced by the Parkinson's disease-related protein alpha-synuclein (?-syn), which is known to induce the accumulation of ROS.

SUBMITTER: Lee YJ

PROVIDER: S-EPMC3195900 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Triclabendazole protects yeast and mammalian cells from oxidative stress: identification of a potential neuroprotective compound.

Lee Yong Joo YJ Burlet Elodie E Wang Shaoxiao S Xu Baoshan B Huang Shile S Galiano Floyd J FJ Witt Stephan N SN

Biochemical and biophysical research communications 20110916 1

The Prestwick and NIH chemical libraries were screened for drugs that protect baker's yeast from sugar-induced cell death (SICD). SICD is triggered when stationary-phase yeast cells are transferred from spent rich medium into water with 2% glucose and no other nutrients. The rapid, apoptotic cell death occurs because reactive oxygen species (ROS) accumulate. We found that triclabendazole, which is used to treat liver flukes in cattle and man, partially protects against SICD. Characterization of ...[more]

PMID: 21946065

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Dataset Information

Triclabendazole protects yeast and mammalian cells from oxidative stress: identification of a potential neuroprotective compound.

Publications

Triclabendazole protects yeast and mammalian cells from oxidative stress: identification of a potential neuroprotective compound.

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