In vivo tumor targeting by a NGR-decorated micelle of a recombinant diblock copolypeptide.

ABSTRACT: Antivascular targeting is a promising strategy for tumor therapy. This strategy has the potential to overcome many of the transport barriers associated with targeting tumor cells in solid tumors, because the tumor vasculature is directly accessible to targeting vehicles in systemic circulation. We report a novel nanoscale delivery system consisting of multivalent polymer micelles to target receptors that are preferentially upregulated in the tumor vasculature and perivascular cells, specifically CD13. To this end we utilized amphiphilic block copolymers, composed of a genetically engineered elastin-like polypeptide (ELP) that self-assemble into monodisperse spherical micelles. These polymer micelles were functionalized by incorporating the NGR tripeptide ligand, which targets the CD13 rece

SUBMITTER: Simnick AJ 

PROVIDER: S-EPMC3196042 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature