Widespread endogenization of densoviruses and parvoviruses in animal and human genomes.

ABSTRACT: Parvoviruses infect humans and a broad range of animals, from mammals to crustaceans, and generally are associated with a variety of acute and chronic diseases. However, many others cause persistent infections and are not known to be associated with any disease. Viral persistence is likely related to the ability to integrate into the chromosomal DNA and to establish a latent infection. However, there is little evidence for genome integration of parvoviral DNA except for Adeno-associated virus (AAV). Here we performed a systematic search for homologs of parvoviral proteins in publicly available eukaryotic genome databases followed by experimental verification and phylogenetic analysis. We conclude that parvoviruses have frequently invaded the germ lines of diverse animal species, including

SUBMITTER: Liu H 

PROVIDER: S-EPMC3196449 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature