Reassortment events among swine influenza A viruses in China: implications for the origin of the 2009 influenza pandemic.

ABSTRACT: That pigs may play a pivotal role in the emergence of pandemic influenza was indicated by the recent H1N1/2009 human pandemic, likely caused by a reassortant between viruses of the American triple-reassortant (TR) and Eurasian avian-like (EA) swine influenza lineages. As China has the largest human and pig populations in the world and is the only place where both TR and EA viruses have been reported to cocirculate, it is potentially the source of the H1N1/2009 pandemic virus. To examine this, the genome sequences of 405 swine influenza viruses from China were analyzed. Thirty-six TR and EA reassortant viruses were identified before and after the occurrence of the pandemic. Several of these TR-EA reassortant viruses had genotypes with most segments having the same lineage origin as the segm

SUBMITTER: Lam TT 

PROVIDER: S-EPMC3196454 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature