Ebola virion attachment and entry into human macrophages profoundly effects early cellular gene expression.

ABSTRACT: Zaire ebolavirus (ZEBOV) infections are associated with high lethality in primates. ZEBOV primarily targets mononuclear phagocytes, which are activated upon infection and secrete mediators believed to trigger initial stages of pathogenesis. The characterization of the responses of target cells to ZEBOV infection may therefore not only further understanding of pathogenesis but also suggest possible points of therapeutic intervention. Gene expression profiles of primary human macrophages exposed to ZEBOV were determined using DNA microarrays and quantitative PCR to gain insight into the cellular response immediately after cell entry. Significant changes in mRNA concentrations encoding for 88 cellular proteins were observed. Most of these proteins have not yet been implicated in ZEBOV infecti

SUBMITTER: Wahl-Jensen V 

PROVIDER: S-EPMC3196478 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature