Highly diastereoselective and general synthesis of primary β-fluoroamines.

ABSTRACT: A short, high yielding protocol has been developed for the highly diastereoselective (dr >20:1) and general synthesis of primary β-fluoroamines by the enantioselective α-fluorination of aldehydes, conversion into the N-sulfinyl aldimine, nucleophilic addition of various organometallic species, and 1° amine liberation.

SUBMITTER: Schulte ML 

PROVIDER: S-EPMC3196525 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature