Transcriptome profiling of immune responses to cardiomyopathy syndrome (CMS) in Atlantic salmon.

ABSTRACT:

Background

Cardiomyopathy syndrome (CMS) is a disease associated with severe myocarditis primarily in adult farmed Atlantic salmon (Salmo salar L.), caused by a double-stranded RNA virus named piscine myocarditis virus (PMCV) with structural similarities to the Totiviridae family. Here we present the first characterisation of host immune responses to CMS assessed by microarray transcriptome profiling.

Results

Unvaccinated farmed Atlantic salmon post-smolts were infected by intraperitoneal injection of PMCV and developed cardiac pathology consistent with CMS. From analysis of heart samples at several time points and different tissues at early and clinical stages by oligonucleotide microarrays (SIQ2.0 chip), six gene sets representing a broad range of immune responses were ide

SUBMITTER: Timmerhaus G 

PROVIDER: S-EPMC3196748 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature