Progressive genomic instability in the FVB/Kras(LA2) mouse model of lung cancer.

ABSTRACT: Alterations in DNA copy number contribute to the development and progression of cancers and are common in epithelial tumors. We have used array Comparative Genomic Hybridization (aCGH) to visualize DNA copy number alterations across the genomes of lung tumors in the Kras(LA2) model of lung cancer. Copy number gain involving the Kras locus, as focal amplification or whole chromosome gain, is the most common alteration in these tumors and with a prevalence that increased significantly with increasing tumor size. Furthermore, Kras amplification was the only major genomic event among the smallest lung tumors, suggesting that this alteration occurs early during the development of mutant Kras-driven lung cancers. Recurring gains and deletions of other chromosomes occur progressively more frequen

SUBMITTER: To MD 

PROVIDER: S-EPMC3196775 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature