A phenome-based functional analysis of transcription factors in the cereal head blight fungus, Fusarium graminearum.

ABSTRACT: Fusarium graminearum is an important plant pathogen that causes head blight of major cereal crops. The fungus produces mycotoxins that are harmful to animal and human. In this study, a systematic analysis of 17 phenotypes of the mutants in 657 Fusarium graminearum genes encoding putative transcription factors (TFs) resulted in a database of over 11,000 phenotypes (phenome). This database provides comprehensive insights into how this cereal pathogen of global significance regulates traits important for growth, development, stress response, pathogenesis, and toxin production and how transcriptional regulations of these traits are interconnected. In-depth analysis of TFs involved in sexual development revealed that mutations causing defects in perithecia development frequently affect multiple

SUBMITTER: Son H 

PROVIDER: S-EPMC3197617 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature