Association of alcohol dehydrogenase genes with alcohol-related phenotypes in a Native American community sample.

ABSTRACT:

Background

Previous linkage studies, including a study of the Native American population described in the present report, have provided evidence for linkage of alcohol dependence and related traits to chromosome 4q near a cluster of alcohol dehydrogenase (ADH) genes, which encode enzymes of alcohol metabolism.

Methods

The present study tested for associations between alcohol dependence and related traits and 22 single-nucleotide polymorphisms (SNPs) spanning the 7 ADH genes. Participants included 586 adult men and women recruited from 8 contiguous Native American reservations. A structured interview was used to assess DSM-III-R alcohol dependence criteria as well as a set of severe alcohol misuse symptoms and alcohol withdrawal symptoms.

Results

No evidence for associ

SUBMITTER: Gizer IR 

PROVIDER: S-EPMC3197765 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature