Protein interaction-based genome-wide analysis of incident coronary heart disease.

ABSTRACT:

Background

Network-based approaches may leverage genome-wide association (GWA) analysis by testing for the aggregate association across several pathway members. We aimed to examine if networks of genes that represent experimentally determined protein-protein interactions (PPIs) are enriched in genes associated with risk of coronary heart disease (CHD).

Methods and results

Genome-wide association analyses of approximately ≈700,000 single-nucleotide polymorphisms in 899 incident CHD cases and 1823 age- and sex-matched controls within the Nurses' Health and the Health Professionals Follow-up Studies were used to assign genewise P values. A large database of PPIs was used to assemble 8351 unbiased protein complexes and corresponding gene sets. Superimposed genewise P values were

SUBMITTER: Jensen MK 

PROVIDER: S-EPMC3197770 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature