An oat bran meal influences blood insulin levels and related gene sets in peripheral blood mononuclear cells of healthy subjects.

ABSTRACT: The understanding of how fibre-rich meals regulate molecular events at a gene level is limited. This pilot study aimed to investigate changes in gene expression in peripheral blood mononuclear cells (PBMCs) from healthy subjects after consumption of an oat bran-rich meal. Fifteen subjects (8 men and 7 women, aged 20-28 years) ingested meals with oat bran or a control meal after an overnight fast. Blood samples for analysis of postprandial glucose, insulin and triglyceride concentrations were taken during 3 h, while PBMCs for microarray gene expression profiling from five men and five women were taken before and 2 h after the meal. Analysis of transcriptome data was performed with linear mixed models to determine differentially expressed genes in response either to meal intake or meal conte

SUBMITTER: Ulmius M 

PROVIDER: S-EPMC3197843 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature