Estimated glomerular filtration rate and the risk of major vascular events and all-cause mortality: a meta-analysis.

ABSTRACT:

Background

Lower estimated glomerular filtration rate (eGFR) has been associated with an increased risk of major vascular events (MVEs) and death, but differences in methodology make between-study comparisons difficult. We used a novel method to summarise the published results.

Methods and findings

Studies assessing the relationship between baseline eGFR and subsequent MVEs or all cause mortality were identified using Pubmed. Those which involved at least 500 individuals, planned at least 1 year of follow-up, reported age and sex adjusted relative risks, and provided the mean eGFR in each category (or sufficient information to allow its estimation) were included. To take account of differences in underlying risk between studies, proportional within-study differences in eGFR

SUBMITTER: Mafham M 

PROVIDER: S-EPMC3198450 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature