Intraoperative use of tranexamic acid to reduce transfusion rate in patients undergoing radical retropubic prostatectomy: double blind, randomised, placebo controlled trial.

ABSTRACT:

Objectives

To determine the efficacy of intraoperative treatment with low dose tranexamic acid in reducing the rate of perioperative transfusions in patients undergoing radical retropubic prostatectomy.

Design

Double blind, parallel group, randomised, placebo controlled trial.

Setting

One university hospital in Milan, Italy.

Participants

200 patients older than 18 years and undergoing radical retropubic prostatectomy agreed to participate in the trial. Exclusion criteria were atrial fibrillation, coronary artery disease treated with drug eluting stent, severe chronic renal failure, congenital or acquired thrombophilia, and known or suspected allergy to tranexamic acid.

Interventions

Intravenous infusion of tranexamic acid or equivalent volume of placebo

SUBMITTER: Crescenti A 

PROVIDER: S-EPMC3198510 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature