A gene signature in histologically normal surgical margins is predictive of oral carcinoma recurrence.

ABSTRACT:

Background

Oral Squamous Cell Carcinoma (OSCC) is a major cause of cancer death worldwide, which is mainly due to recurrence leading to treatment failure and patient death. Histological status of surgical margins is a currently available assessment for recurrence risk in OSCC; however histological status does not predict recurrence, even in patients with histologically negative margins. Therefore, molecular analysis of histologically normal resection margins and the corresponding OSCC may aid in identifying a gene signature predictive of recurrence.

Methods

We used a meta-analysis of 199 samples (OSCCs and normal oral tissues) from five public microarray datasets, in addition to our microarray analysis of 96 OSCCs and histologically normal margins from 24 patients, to train

SUBMITTER: Reis PP 

PROVIDER: S-EPMC3198722 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature