Association of chemerin mRNA expression in human epicardial adipose tissue with coronary atherosclerosis.

ABSTRACT:

Background

Growing evidence suggests that epicardial adipose tissue (EAT) may play a key role in the pathogenesis and development of coronary artery disease (CAD) by producing several inflammatory adipokines. Chemerin, a novel adipokine, has been reported to be involved in regulating immune responses and glucolipid metabolism. Given these properties, chemerin may provide an interesting link between obesity, inflammation and atherosclerosis. In this study, we sought to determine the relationship of chemerin expression in EAT and the severity of coronary atherosclerosis in Han Chinese patients.

Methods

Serums and adipose tissue biopsies (epicardial and thoracic subcutaneous) were obtained from CAD (n = 37) and NCAD (n = 16) patients undergoing elective cardiac surgery. Gensini

SUBMITTER: Gao X 

PROVIDER: S-EPMC3198902 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature