Age-related changes in the default mode network are more advanced in Alzheimer disease.

ABSTRACT:

Objective

To investigate age-related default mode network (DMN) connectivity in a large cognitively normal elderly cohort and in patients with Alzheimer disease (AD) compared with age-, gender-, and education-matched controls.

Methods

We analyzed task-free-fMRI data with both independent component analysis and seed-based analysis to identify anterior and posterior DMNs. We investigated age-related changes in connectivity in a sample of 341 cognitively normal subjects. We then compared 28 patients with AD with 56 cognitively normal noncarriers of the APOE ε4 allele matched for age, education, and gender.

Results

The anterior DMN shows age-associated increases and decreases in fontal lobe connectivity, whereas the posterior DMN shows mainly age-associated declines in co

SUBMITTER: Jones DT 

PROVIDER: S-EPMC3198977 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature