Cardiovascular disease and cognitive function in maintenance hemodialysis patients.

ABSTRACT:

Background

Cardiovascular disease (CVD) and cognitive impairment are common in dialysis patients. Given the proposed role of microvascular disease on cognitive function, particularly cognitive domains that incorporate executive functions, we hypothesized that prevalent systemic CVD would be associated with worse cognitive performance in hemodialysis patients.

Design

Cross-sectional cohort.

Setting & participants

200 maintenance hemodialysis patients without prior stroke from 5 Boston-area hemodialysis units.

Predictor

CVD, defined as history of coronary disease or peripheral vascular disease.

Outcome

Performance on a detailed neurocognitive battery. Primary analyses quantified cognitive performance using principal components analysis to reduce cognitive

SUBMITTER: Weiner DE 

PROVIDER: S-EPMC3199371 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature