CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.

ABSTRACT: The epigenetic changes of the chromatin represent an attractive molecular substrate for adaptation to the environment. We examined here the role of CREB-binding protein (CBP), a histone acetyltransferase involved in mental retardation, in the genesis and maintenance of long-lasting systemic and behavioural adaptations to environmental enrichment (EE). Morphological and behavioural analyses demonstrated that EE ameliorates deficits associated to CBP deficiency. However, CBP-deficient mice also showed a strong defect in environment-induced neurogenesis and impaired EE-mediated enhancement of spatial navigation and pattern separation ability. These defects correlated with an attenuation of the transcriptional programme induced in response to EE and with deficits in histone acetylation at the

SUBMITTER: Lopez-Atalaya JP 

PROVIDER: S-EPMC3199387 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature