Ontology highlight
ABSTRACT:
SUBMITTER: Chong S
PROVIDER: S-EPMC3199608 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Nature genetics 20070422 5
There is increasing evidence that epigenetic information can be inherited across generations in mammals, despite extensive reprogramming both in the gametes and in the early developing embryo. One corollary to this is that disrupting the establishment of epigenetic state in the gametes of a parent, as a result of heterozygosity for mutations in genes involved in reprogramming, could affect the phenotype of offspring that do not inherit the mutant allele. Here we show that such effects do occur f ...[more]