The Histone Database: an integrated resource for histones and histone fold-containing proteins.

ABSTRACT: Eukaryotic chromatin is composed of DNA and protein components-core histones-that act to compactly pack the DNA into nucleosomes, the fundamental building blocks of chromatin. These nucleosomes are connected to adjacent nucleosomes by linker histones. Nucleosomes are highly dynamic and, through various core histone post-translational modifications and incorporation of diverse histone variants, can serve as epigenetic marks to control processes such as gene expression and recombination. The Histone Sequence Database is a curated collection of sequences and structures of histones and non-histone proteins containing histone folds, assembled from major public databases. Here, we report a substantial increase in the number of sequences and taxonomic coverage for histone and histone fold-contain

SUBMITTER: Marino-Ramirez L 

PROVIDER: S-EPMC3199919 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature