Matrix Gla protein polymorphism, but not concentrations, is associated with radiographic hand osteoarthritis.

ABSTRACT:

Objective

Factors associated with mineralization and osteophyte formation in osteoarthritis (OA) are incompletely understood. Genetic polymorphisms of matrix Gla protein (MGP), a mineralization inhibitor, have been associated clinically with conditions of abnormal calcification. We therefore evaluated the relationship of MGP concentrations and polymorphisms at the MGP locus to hand OA.

Methods

Ours was an ancillary study to a 3-year randomized trial assessing the effect of vitamin K supplementation on vascular calcification and bone loss among community-dwelling elders. We studied participants who had serum MGP concentration measured and DNA genotyped for 3 MGP genetic polymorphisms (rs1800802, rs1800801, and rs4236), and who had hand radiographs. We evaluated the cross-sect

SUBMITTER: Misra D 

PROVIDER: S-EPMC3200118 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature