Cardiac natriuretic peptides, obesity, and insulin resistance: evidence from two community-based studies.

ABSTRACT:

Background

The natriuretic peptides play an important role in salt homeostasis and blood pressure regulation. It has been suggested that obesity promotes a relative natriuretic peptide deficiency, but this has been a variable finding in prior studies and the cause is unknown.

Aim

The aim of this study was to examine the association between obesity and natriuretic peptide levels and evaluate the role of hyperinsulinemia and testosterone as mediators of this interaction.

Methods

We studied 7770 individuals from the Framingham Heart Study (n = 3833, 54% women) and the Malmö Diet and Cancer study (n = 3918, 60% women). We examined the relation of plasma N-terminal pro-B-type natriuretic peptide levels (N-BNP) with obesity, insulin resistance, and various metabolic subtype

SUBMITTER: Khan AM 

PROVIDER: S-EPMC3200240 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature