Metformin and/or clomiphene do not adversely affect liver or renal function in women with polycystic ovary syndrome.

ABSTRACT:

Context

Nonalcoholic fatty liver disease is common to insulin-resistant states such as polycystic ovary syndrome (PCOS). Metformin (MET) is often used to treat PCOS but information is limited as to its effects on liver function.

Objective

We sought to determine the effects of MET on serum hepatic parameters in PCOS patients.

Design

This was a secondary analysis of a randomized, doubled-blind trial from 2002-2004.

Setting

This multi-center clinical trial was conducted in academic centers.

Patients

Six hundred twenty-six infertile women with PCOS with serum liver function parameters less than twice the upper limit of normal were included.

Interventions

Clomiphene citrate (n = 209), MET (n = 208), or combined (n = 209) were given for up to 6 months.<

SUBMITTER: Aubuchon M 

PROVIDER: S-EPMC3200244 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature