Heritability of the weight loss response to gastric bypass surgery.

ABSTRACT:

Context

The use of Roux-en-Y gastric bypass (RYGB) surgery to treat severe obesity has grown dramatically. RYGB is highly effective, but the response in individual patients varies widely, and clinical predictors have been able to explain only a fraction of this variation.

Objective

Our objective was to determine whether there is a significant genetic contribution to weight loss after RYGB.

Methods

We genotyped 848 patients undergoing RYGB. Using identity-by-descent methods, we identified 13 pairs of first-degree relatives. We identified an additional 10 pairs of individuals who were living together but are not genetically related and randomly paired the remaining 794 individuals. We then compared weight loss within and across pairs.

Results

First-degree relativ

SUBMITTER: Hatoum IJ 

PROVIDER: S-EPMC3200251 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature