In vivo imaging of rat coronary arteries using bi-plane digital subtraction angiography.

ABSTRACT:

Introduction

X-ray based digital subtraction angiography (DSA) is a common clinical imaging method for vascular morphology and function. Coronary artery characterization is one of its most important applications. We show that bi-plane DSA of rat coronary arteries can provide a powerful imaging tool for translational safety assessment in drug discovery.

Methods

A novel, dual tube/detector system, constructed explicitly for preclinical imaging, supports image acquisition at 10 frames/s with 88-micron spatial resolution. Ventilation, x-ray exposure, and contrast injection are all precisely synchronized using a biological sequence controller implemented as a LabVIEW application. A set of experiments were performed to test and optimize the sampling and image quality. We applied t

SUBMITTER: Badea CT 

PROVIDER: S-EPMC3200458 | biostudies-literature | 2011 Sep-Oct

REPOSITORIES: biostudies-literature