Identification of transcriptional regulatory networks specific to pilocytic astrocytoma.

ABSTRACT:

Background

Pilocytic Astrocytomas (PAs) are common low-grade central nervous system malignancies for which few recurrent and specific genetic alterations have been identified. In an effort to better understand the molecular biology underlying the pathogenesis of these pediatric brain tumors, we performed higher-order transcriptional network analysis of a large gene expression dataset to identify gene regulatory pathways that are specific to this tumor type, relative to other, more aggressive glial or histologically distinct brain tumours.

Methods

RNA derived from frozen human PA tumours was subjected to microarray-based gene expression profiling, using Affymetrix U133Plus2 GeneChip microarrays. This data set was compared to similar data sets previously generated from non-mal

SUBMITTER: Deshmukh H 

PROVIDER: S-EPMC3200988 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature