A novel reporter of notch signalling indicates regulated and random Notch activation during vertebrate neurogenesis.

ABSTRACT:

Background

Building the complex vertebrate nervous system involves the regulated production of neurons and glia while maintaining a progenitor cell population. Neurogenesis starts asynchronously in different regions of the embryo and occurs over a long period of time, allowing progenitor cells to be exposed to multiple extrinsic signals that regulate the production of different cell types. Notch-mediated cell-cell signalling is one of the mechanisms that maintain the progenitor pool, however, little is known about how the timing of Notch activation is related to the cell cycle and the distinct modes of cell division that generate neurons. An essential tool with which to investigate the role of Notch signalling on cell by cell basis is the development a faithful reporter of Notch ac

SUBMITTER: Vilas-Boas F 

PROVIDER: S-EPMC3201213 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature