Gender and acute respiratory distress syndrome in critically injured adults: a prospective study.

ABSTRACT:

Background

The acute respiratory distress syndrome (ARDS) is a proinflammatory condition that often complicates trauma and critical illness. Animal studies have shown that both gender and sex hormones play an important role in inflammatory regulation. Human data are scant regarding the role of gender and sex hormones in developing ARDS. Our objective was to describe gender and hormonal differences in patients who develop ARDS in a large cohort of critically injured adults.

Methods

A prospective cohort study of adult trauma patients requiring intensive care unit admission for at least 48 hours was performed. Demographic and clinical data were collected prospectively, and sex hormones were assayed at study entry (48 hours). The primary outcome was the development of ARDS. Mult

SUBMITTER: Heffernan DS 

PROVIDER: S-EPMC3201740 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature