Ontology highlight
ABSTRACT:
SUBMITTER: Cuenca-Bono B
PROVIDER: S-EPMC3201862 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Cuenca-Bono Bernardo B García-Molinero Varinia V Pascual-García Pau P Dopazo Hernan H Llopis Ana A Vilardell Josep J Rodríguez-Navarro Susana S
Nucleic acids research 20110712 19
Efficient coupling between mRNA synthesis and export is essential for gene expression. Sus1/ENY2, a component of the SAGA and TREX-2 complexes, is involved in both transcription and mRNA export. While most yeast genes lack introns, we previously reported that yeast SUS1 bears two. Here we show that this feature is evolutionarily conserved and critical for Sus1 function. We determine that while SUS1 splicing is inefficient, it responds to cellular conditions, and intronic mutations either promoti ...[more]